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doi: 10.3390/ijms19072116 78

Specifically, colistin significantly promotes the upregulation of HDAC1 expression and leads to the deacetylation of histone 3 lysine 27 (H3K27) in the Nrf2 (the master regulator of anti-oxidant response) promoter region to inhibit the activity of the Nrf2 signaling pathway